Regina E. O'Brien passed away on March 28, 2022 at the age of 73. Beloved Daughter of the late John and Helen O'Brien. Sister of Kevin and Eileen McQuaid. Loving Aunt of Lauren Mattiacci (John). Dear meme of Lily, Melody, Meadow, Owen and Ivy. Best friend of Colleen, Maggie, Ginger and Kathy. Relatives and friends are invited to gather Wednesday April 6 ^th , 2022 from 10:00AM to 11:00AM at 1428 East Columbia Avenue Philadelphia, PA 19125. Followed by her service at 11:00AM. Interment Private.